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The exact cause of sarcoidosis is not known since many factors may cause the disease. It is comprised of an abnormal immune response and formation of cell clusters called granulomas. Sarcoidosis can be present in the lungs (pulmonary), or it may be in other areas such as the eye, heart, or kidneys (extrapulmonary) Sarcoidosis may be limited, or it can progressively become debilitating.

Pulmonary symptoms include a persistent cough, wheezing, and shortness of breath. Extrapulmonary symptoms include skin rashes, swollen lymph nodes, fatigue, fever, and joint pain. A biopsy is typically required for a proper diagnosis.